More news re Sinovac from BMJ

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compass
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More news re Sinovac from BMJ

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Post by compass »

This is the latest from the British Medical Journal.

What vaccines has China developed?
There are about a dozen Chinese vaccine candidates for covid-19, but five front runners have received emergency use approval in China as well as several other countries.

Sinopharm, a state owned enterprise, is currently working on two different jabs, both of which are based on an inactivated form of SARS-CoV-2. The first was developed at Sinopharm’s Beijing institute while the second was developed in Wuhan. A third vaccine called CoronaVac was developed by the Beijing based pharmaceutical firm Sinovac. It is also based on an inactivated form of SARS-CoV-2.

All three of these require two doses but the fourth front runner, from vaccine developer CanSinoBIO, is single dose. Unlike the others, it uses a human adenovirus, Ad5, to deliver SARS-CoV-2 proteins into the body. (Russia’s Sputnik V vaccine also uses a form of Ad5 as well as another adenovirus.) CanSinoBIO previously used the same approach to develop an Ebola vaccine that was approved for emergency use in China.

A fifth vaccine candidate,1 from pharmaceutical firm Anhui Zhifei Longcom, was given emergency use approval on 16 March. This one requires three doses and uses proteins based on the receptor binding domain of the SARS-CoV-2 virus.

All five of these vaccines can be kept at normal fridge temperatures, a big advantage over others that require storage at extremely cold temperatures.

What clinical trial data are there?
Randomised, double blinded phase I and II trial results for CoronaVac in two age groups—18-59 and 60 and over—were published in the Lancet in November2 and February,3 respectively. The trials found immunogenicity in most patients and that the vaccine was generally safe and well tolerated, with few adverse effects. Phase I and II data for the Anhui Zhifei Longcom vaccine published in March4 showed similar results.

At the time of writing, no phase III trial data for any of the Chinese vaccine candidates have been published in a peer reviewed journal. CanSinoBIO has said it intends to but has given no timeframe.

Most of what we know comes from announcements from the manufacturers and the governments in countries where trials are being conducted. Sinopharm claimed in December that its first vaccine was 79% effective in terms of preventing symptomatic covid-19, based on interim phase III data.5 That is lower than the 86% efficacy reported earlier the same month by the United Arab Emirates,6 one of the countries in which the vaccine has been trialled. Other countries trialling the jab include Bahrain, Egypt, Jordan, and Peru. Sinopharm has also said its second vaccine, from the Wuhan institute, was found to be slightly less effective at 72.5%, based on interim data from phase III trials.7

Also in December, Turkish officials reported interim data from trials showing that Sinovac’s CoronaVac was 91.25% efficacious at preventing symptomatic covid-19 among a subgroup of 1322 participants in a trial involving 7371 people.8 But in January, researchers in Brazil announced that the CoronaVac jab was 78% effective at preventing mild cases, according to information from a phase III trial involving 12 000 healthcare workers in the country.9 Just a week later, additional data emerged, taking into account very mild cases and suggesting that the vaccine was only 50.4% effective against symptomatic covid-19.10 In the same month, authorities in Indonesia said the vaccine, which is being trialled there too, was 65% effective.11

CanSinoBIO’s one dose jab was found to be 75% effective in Pakistan, according to officials there.12 The vaccine is also being trialled in Argentina, Chile, Mexico, and Russia.13

The Associated Press has reported that, according to preliminary data sent to China’s drug regulators, Sinovac is safe for children aged 3 to 17 based on early and mid-stage trials of over 550 subjects.14

How much do they cost?
In December, state media in China reported that Sinopharm and Sinovac intended to charge the government roughly $30 (£22; €26) per dose of their vaccines.15 Detail about the cost of other vaccines developed in China has not been made public.

How are the vaccines being deployed in China?
All five of the leading domestic candidates can be used in China, though it’s unclear how many doses of each have been administered so far, or where. No other vaccines have been approved for use in China.

The country had administered around 120 million doses as of 31 March, according to data published by the National Health Commission and reported by Reuters.16 Zhong Nanshan, a former president of the Chinese Medical Association, told the news agency in early March that China is aiming to vaccinate 40% of its 1.4 billion population by the end of July.17 The country is prioritising 18 to 59 year olds in key worker groups, such as healthcare workers, before moving on to clinically vulnerable people and then those who are aged 60 or over.18

Authorities behind Hong Kong’s mass free vaccination programme have said that three centres originally set to offer the Pfizer vaccine would switch to Sinovac in response to strong public demand to be vaccinated as soon as possible.

Because of the lack of transparency surrounding Chinese made vaccines, however, vaccine hesitancy appears to be a problem. A survey by China’s disease control and prevention centre found that just 42% of healthcare and epidemic preparedness workers were willing to have a vaccine during a recent rollout.19 There are reports of similar hesitancy in Brazil; in a recent poll in the country, just 47% of respondents said they would be willing to take a vaccine made in China.20

Which of China’s vaccines have been approved outside of China?
Sinopharm’s first vaccine has received the most emergency use approvals so far, nearly 30, including in Bahrain, Guyana, Hungary, Serbia, and the UAE. Hungary was the first EU country to approve use of a Chinese vaccine, with Prime Minister Viktor Orbán among those who have received it.

Several countries have approved Sinovac’s CoronaVac jab for emergency use, including Brazil, Chile (where the vaccine has been trialled), Indonesia, Laos, Mexico, and Turkey.

Mexico and Pakistan have given emergency use approval to the CanSinoBIO vaccine.

The Anhui Zhifei Longcom vaccine has received approval for use in Uzbekistan.

Which countries have received Chinese vaccines?
Chinese firms have appeared keen to supply countries with plenty of doses of their vaccines, beyond those merely required to carry out clinical trials. For example, 223 million doses of Sinopharm jabs have already been distributed to various countries around the world. In some countries, the value of deals remains undisclosed but the New York Times reported that Hungary paid $36 per dose for the Sinopharm jab.21 In Senegal, a lower price was achieved22—just $19 per dose in a deal supplying 200 000 Sinopharm doses to the African country.

Some nations are relying heavily on Chinese vaccines for their covid-19 vaccination programmes. The majority of those administered by the UAE, for example, are made by Sinopharm. Serbia looks set to receive another 500 000 Sinopharm doses, having already taken delivery of 1.5 million. Cambodia and Egypt have received shipments of 300 000 doses at a time.

Meanwhile, countries trialling Sinovac’s vaccine have received large numbers of doses already. Indonesia, for instance, has had 28 million doses at the time of writing. Chile has received five shipments according to China’s state media23 although the exact number of doses is unclear

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Re: More news re Sinovac from BMJ

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Post by kibsolar1999 »

well not very convincing...

btw, has anybody a clue how many doses of Sinovac, BioNtech and AZ has arrived in NC till today?

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Post by waddo »

For myself, I would rather have a vaccine that is 50% effective than not have one at all.

Have already had the two doses of the Chinese vaccine and no after effects, so it either is working or it is not - 50/50 - social distancing, sanitization and of course wearing my mask to protect YOU from ME has either worked or not - 50/50. Statistics on the multitude of available vaccines differ wildly, with the larger well known Big Pharma's claiming the best results as normal.

It will take some long time - possibly years - to find a single most effective vaccine but in the meantime it is a case of pay your money and take your chance, or do nothing and take your chance. I am amazed that some people still consider this virus to be simply a flu that has been blown out of all proportion by various Governments and they also refuse to have any vaccination unless they are forced to, not because they are afraid of the injection itself but because they do not believe it is necessary - horse for courses. Stay safe out there.
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Post by Brazen »

waddo wrote:
Sun 11 Apr 2021 6:31 pm
For myself, I would rather have a vaccine that is 50% effective than not have one at all.

Have already had the two doses of the Chinese vaccine and no after effects, so it either is working or it is not - 50/50 - social distancing, sanitization and of course wearing my mask to protect YOU from ME has either worked or not - 50/50. Statistics on the multitude of available vaccines differ wildly, with the larger well known Big Pharma's claiming the best results as normal.

It will take some long time - possibly years - to find a single most effective vaccine but in the meantime it is a case of pay your money and take your chance, or do nothing and take your chance. I am amazed that some people still consider this virus to be simply a flu that has been blown out of all proportion by various Governments and they also refuse to have any vaccination unless they are forced to, not because they are afraid of the injection itself but because they do not believe it is necessary - horse for courses. Stay safe out there.
Totally agree. Some people believe the virus is a conspiracy to gain control over populations and that the vaccinations are intoducing microchips into our bodies.

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Post by waddo »

Brazen, don’t forget the other bunch that won’t have a PCR test because it destroys the mucus membranes in your nose and that’s how cancer gets in! Oh yes, they are all amongst us, why people still don’t believe that the earth is flat is quite beyond me - lol.
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Post by Yorkie »

Report today in the Mail regards Chinese vaccine:
https://www.dailymail.co.uk/news/articl ... C201D73041

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Post by kibsolar1999 »

so, i take it then that nobody has a clue how many doses did arrive in NC and how many of them were given to whom.

??

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